This Quick Reference Guide is a practical guide for all stakeholders who hope to implement a government-led, cross-border coordination mechanism for the protection of children who are unaccompanied and separated while in situations of migration or displacement. It highlights why cross-border coordination mechanisms are important and how they can be developed. The Quick Reference Guide is designed for adaptation or replication in East and Southern Africa, and possibly other contexts, by delivering accessible and clear guidance on the why and the how.