The Global Covid-19 Associated Orphanhood webinar took place on 6 October 2021 and brought together leading scientists and technical experts in the federal government and non-government organizations. The COVID-19 pandemic is destined to leave millions more children without family caregivers. Increases in mortality of parents and other caregivers in the COVID-19 pandemic are accompanied by increases in extreme vulnerability from loss of livelihoods, schooling, health recovery and usual sources of service provision and support. This is a critical moment to understand how COVID-19 will affect the lives of children, how lessons learned from prior emergencies can be adapted, and how an understanding of complex adversities can maximize the effectiveness of our response.