Institutional Care is Associated With Changes in Brain Electrical Activity: Results From a Longitudinal, Randomized Control Trial of Children in Romania

Ranjan Debnath, Alva Tang, George A. Buzzell, Nathan A. Fox, Charles H. Zeanah, Charles A. Nelson - Biological Psychiatry

This study from the Bucharest Early Intervention Project (BEIP) examines the brain electrical activity of children and young people who have been institutionalized. Exposure to early psychosocial deprivation as a result of institutional care disrupts typical brain development. The Bucharest Early Intervention Project (BEIP) is the first longitudinal study to investigate the neurodevelopment of institutionalized infants randomized to foster care (FCG) versus care as usual (CAUG). Our previous work suggested that foster care placement, particularly before 24 months of age, significantly improved brain functioning compared to CAUG at 42 months and age 8. Here, we examined the brain electrical activity among the CAUG, FCG who were enrolled in the BEIP and never institutionalized (NIG) adolescents at age 16.