"Left-behind children" refer to children whose parents or one of them go out to work in the city all year round. Due to the education conditions in the city, they stay alone in the countryside. Because they are separated from their parents all the year round, the lack of good family education in their growth environment has brought many negative effects on their growth and also caused more serious social problems. It can be seen that the research on the family education of left-behind children in rural areas is very necessary. Therefore, this study takes G Village in Guizhou Province as an example. This study includes literature review and a interview of 40 left-behind children and 20 guardians in G Village, Guizhou Province. Also, the physical and mental health and safety hazards of left-behind children and their causes were analyzed. The result of the study is that the absence of parents has a major impact on the physical and mental health of most left-behind children. The huge negative impact caused the alienation of their growth environment. Regarding this problem, this article believes that the corresponding countermeasures from the family, school, society, and government are proposed. The main purpose is to pay attention to the special group of left-behind children, combining the various forces of society, and giving them more care. Let the left-behind children whose parents are absent grow up healthily.