Orphan-hood is a natural occurrence event of life and not a personal choice. It is a natural life event of losing a parent or a primary caregiver in the life of an orphan child. This chapter from Addressing Multicultural Needs in School Guidance and Counseling focuses on the psychological and social issues that orphans and other vulnerable children experience when their parents are no longer alive. Using literature as a source, most psychosocial issues affecting orphans and other vulnerable children are categorized and justified. Possible solutions and recommendations are clearly illustrated for possible intervention and prevention strategies. Lastly, the chapter ushers future research directions regarding psychosocial issues affecting orphans and other vulnerable children.