Kinship care is one of the most prevalent forms of placement that is used for children affected and/or infected by HIV and AIDS in Namibia. However, the literature lacks a systematic theory-informed understanding with respect to what is currently known about caregivers generally and specifically, elderly caregivers of orphans, and vulnerable children (OVC) in sub-Saharan Africa. This foundational chapter from Biopsychosocial Perspectives and Practices for Addressing Communicable and Non-Communicable Diseases attempts to provide readers with content to assist in their understanding of the characteristics, role, and experiences of kinship elderly caregivers of children affected and/or infected by HIV and AIDS. In addition, the chapter highlights what is known about children living with HIV in Namibia. Finally, the chapter offers suggestions for policy and practice.