An op-ed from Sean Callahan of Catholic Relief Services, Georgette Mulheir of Lumos Foundation, and Philip Goldman of Maestral International describe their partnership to prevent children from entering orphanages and transition to systems supporting vulnerable children in family-based care around the world. The article describes their proposal to support the transformation of care systems, which has been named a semi-finalist for a $100 million grant from the MacArthur Foundation, called "100 & Change."