The International HIV/AIDS Alliance is a global alliance of 40 organisations that work with communities on HIV, health and human rights initiatives, including support for orphans and vulnerable children.

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GHR Foundation is a design-build philanthropy creating change with their partners around the world in the areas of global development, education and health.

The Global Allience for Children seeks to create platforms through which multi-sector partners can deliver measurable results for children deprived of safe, nurturing family based care. Global Alliance for Children is a coalition of foundations, multilateral and bilateral agencies, governments, universities, corporations, implementing agencies and individual experts working together to ensure that children realize their full developmental potential within nurturing, protective family based care.

The Global Initiative to End All Corporal Punishment of Children promotes universal prohibition and elimination of corporal punishment. Supporters of this aim include UNICEF, UNESCO and many international and national organisations and prominent individuals.

The Global Movement for Children (GMC) is the worldwide movement of organisations, people and children uniting efforts to build a world fit for children.
 

The Global Orphan Project is a Christian faith-based organization that seeks innovative ways to expand the capacity of churches to care for vulnerable children and families in their own communities. Around the world, the Global Orphan Project supports local churches to care for children through church-centered orphan care, transition, education and family-strengthening programs. In the U.S., they connect at-risk children served by the child welfare system to churches and individuals who want to help.

The GPcwd provides a platform for collective action and advocacy to ensure that the rights of children with disabilities are included in and prioritized by both the disability and child rights agendas at the global, regional, and country levels. The GPcwd Partnership is a global multi-stakeholder coalition, representing more than 260 organizations, including international, national and local non-governmental organizations (NGOs); disabled people’s organizations (DPOs); academia; young advocates; governments and the private sector.
 

The Global Partnership to End Violence Against Children was launched in July 2016 by the UN Secretary-General. Today, the End Violence Partnership is the only global entity focused solely on Sustainable Development Goal 16.2: ending all forms of violence against children. The Partnership is made up of over 500 partners, including governments, UN agencies, research institutions, international non-governmental organisations, foundations, civil society organisations, private sector groups, and more. 

The Global Social Service Workforce Alliance aims to strengthen the social service workforce and to contribute to stronger, more effective social service systems around the world. The Global Social Service Workforce Alliance works toward a world where a well-planned, well-trained and well-supported social service workforce effectively delivers promising practices that improve the lives of vulnerable populations.

GOAL's mission is "to work towards ensuring that the poorest and most vulnerable in our world and those affected by humanitarian crises have access to the fundamental rights of life, including but not limited to adequate shelter, food, water and sanitation, healthcare and education." GOAL’s Children's Empowerment and Protection (CEP) sector focuses on high vulnerability populations of children, often in the most extreme of situations (e.g. street children, child prostitutes and child migrant labourers).