The Center on the Developing Child’s diverse activities align around building an R&D (research and development) platform for science-based innovation, and transforming the policy and practice landscape that supports and even demands change. The Center promotes this work because society pays a huge price when children do not reach their potential, half a century of policies and programs have not produced breakthrough outcomes, and dramatic advances in science are ready to be used to achieve a promising future for every child. The Center on the Developing Child’s R&D (research and development) platform, Frontiers of Innovation (FOI), supports scientific research that can inform the testing, implementation, and refinement of strategies designed to achieve significantly better life outcomes for children facing adversity. One of its focus areas for research and innovation is neglect, particularly chronic neglect, and its impact on brain development, physical and mental health, and socio-emotional wellbeing.