The Children's Rights Centre is committed to the protection of children achieving their potential. Their website has information regarding children's rights including: Policy and laws that uphold children's rights, such as the African Charter on the Rights and Welfare of the Child, the United Nation's Convention on the Rights of the Child, South African Bill of Rights, and others. The website also features resources, news, and advocacy campaigns on particular issues affecting children such as education, family life, discipline, poverty, violence, HIV/AIDS, disability, and many others, as well as the voices of children themselves especially in the photo-documentary "Visions & Voices: Children's Rights & Realities". 

The Children's Rights Centre also initiated the Yezingane Network. The Yezingane Network is a civil society network made up of organisations working to address the impact of HIV and AIDS on children, families and communities. Initially known as the SANAC Children’s Sector Network, the organization was formed in 2003 after the Children’s Rights Centre called for better representation of children’s issues on SANAC and the NGO Sector recommended to SANAC that the Children’s Sector be represented in its own right in the SANAC Council.

The Network represents the Children’s Sector on the South African National AIDS Council (SANAC), and is one of nineteen Sectors that constitute the Council. South Africa is the first, and to date the only country where the Children’s Sector has succeeded in having direct representation on a National AIDS Council. The Network is goal-driven and it’s members serve the interests of common purpose, with shared expectations of a changed society for children and HIV and AIDS. The core concern of Yezingane Network is ensuring that HIV and children’s rights are not seen as separate issues.

Children Affected by HIV/AIDS, Children Living in Poverty