The threat of the global COVID-19 pandemic reaching the Kutupalong refugee camp in Bangladesh represents a multitude of child protection risks, including the risk of family/caregiver separation or loss due to the disease. This guidance note has been developed as a framework for minimum preparedness and response actions for a potential increase in the number of unaccompanied or separated children in need of alternative care. In line with the Child Protection Minimum Standards, alternative care should remain a last resort, applicable only when it is demonstrably in the best interest of the child. Family-based care is significantly preferred to residential care. Remember that a key guiding principle is to maintain family unity.