Climate change poses a significant threat to global health, with serious implications for mental health and overall well-being among children and adolescents, particularly in sub-Saharan Africa. Existing structural vulnerabilities intensify the impact of climate-related stressors. Current responses largely focus on awareness and post-disaster support and remain insufficient for building long-term resilience. This paper calls for preventive, evidence-based combination interventions that integrate climate change education with family-strengthening and economic empowerment strategies. By enhancing household stability, family functioning, and adaptive capacity, these approaches can mitigate the adverse impacts of climate change. Coordinated, multisectoral efforts are essential to protect vulnerable children and families in an increasingly unstable climate.