This article presents the Care Leaver Statistics (CLS) study, the first nationwide panel study in Germany focused on young people leaving out-of-home care, like foster or residential care. It follows about 1,500 youth aged 16–19 over several years to understand their life transitions, including education, employment, housing, health, social networks, and societal participation. The study also emphasizes ethical research practices, diversity sensitivity, and participatory methods that can empower care-experienced youth.