In the current protection crisis unfolding in Ukraine, humanitarian actors must pay particular attention to those who are most at risk of threats to safety and rights violations – including women, children, older people, and people who are blind and/or deaf, persons with psychosocial and intellectual disabilities, those who have mobility limitations, and persons with high support needs. In this brief, the Global Protection Cluster calls on all parties to the conflict and humanitarian actors to ensure the protection and safety of persons with disabilities in Ukraine.