This study aimed to investigate the relationship between mindfulness and psychological well-being, with a particular focus on the moderating effect of self-efficacy of orphanage adolescents. A sample of 150 participants, including 89 males and 61 females were gathered and completed a set of self-report measures, including the Mindfulness Attention Awareness Scale (MAAS), General Self-Efficacy Scale urdu (GSE), and the Psychological Well-being Scale urdu version (PWB). The results were analyzed using process by hayes to evaluate the moderating effect, liner regression was done to identify the predictor of self-efficacy and t test was done to evaluate the mean relation between mindfulness and psychological wellbeing. Results indicated a significant positive relationship between mindfulness and psychological well-being and demonstrated that self-efficacy moderates this relationship. Specifically, individuals with higher levels of self-efficacy demonstrated a stronger relationship between mindfulness and psychological well-being compared to those with lower levels of self-efficacy. The study will promote mental health of orphanage Adolescents in Pakistan by highlighting the importance of mindfulness, self-efficacy, and psychological wellbeing
