This chapter in the The Routledge Handbook of Social Work and Migration focuses on social work with children and young people who have experienced forced migration and become separated from family members, known as unaccompanied minors. It considers the ways in which young people may become separated from parents in the context of youth migration. The chapter explores the possibilities of rights-based practice with unaccompanied children and considers what might be needed to develop and sustain this. It takes five areas of practice, as examples, to explore rights-based approaches to social work: participation, international protection, accommodation, transnational family life and age assessment. The challenges and opportunities of approaching these areas within a rights-based framework are explored and the implications and messages for practice are identified. Although it is written from a UK perspective, it is relevant for social work with unaccompanied young people in Europe and internationally.