This manual is the main outcome of the European Commission Daphne III programme, Prevent and Combat Child Abuse: What works? Involving regional exchanges and research from five countries (Germany, Hungary, Portugal, Sweden and the Netherlands), this manual brings together knowledge on what works in tackling child abuse. The manual suggests evidence and practice-based prevention and response strategies against child abuse and neglect, including programs and services that have been shown to be successful in strengthening family care.